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Well, both cleanse the colon. But what’s usually called “colon cleansing” nowadays is the use of some kind of pill that has a laxative effect. Its intent is to clear out the intestine. Colonic irrigation is just what it says — irrigating the colon with water to flush it out. It’s what you might call an “ultra enema”. It’s done in a clinic or spa by a licensed therapist who inserts an inch-wide tube into your rectum and then gently pumps many gallons of water into your intestine over the course of about 45 minutes. Whenever you feel you need to release, the in flow is ceased while the water drains out of you. After releasing, you’re given more fills. Colonics are pretty controversial (as are colon cleansing pills, really) and you should do your research if you’re considering it.