Fatigue can happen in Multiple Sclerosis, and those who deal with hypothyroidism. TSH levels, which can go over 5.3 hypothyroidism. After a total thyroidectomy in January 2008, my TSH went up to 42 – I was pretty wiped out. I’m back to work down toward a normal TSH and dealing with all the pollution along the path. Hypothyroidism and MS seem a lot alike in some way. Many “UMMS” and some “yawn” – excuse me, around you to yawn, even the word is contagious:)