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Why the statins (simvastatin and other lypodecreasing drugs) are prescribed to be taken before bed time?
Question : Why the statins (simvastatin and other lypodecreasing drugs) are prescribed to be taken before bed time?
I mean why is it better to take statins before bedtime (at evening) than at morning. F.e. the h2-blockers are taken at evening because more hystamin is secreted at night so the effect of the drug will be better. So what effect of the statins will be better if they r taken at night?
statins
Best answer:
Answer by muddypuppyuk
Other factors include once a day doses that might or do cause drowsiness to be taken at night, or drugs that react with foods to be taken when one is not going to be eating, such as bed time.
The reason that the earlier available statins were recommended for use at night was because they had relatively short half lives, and bedtime administration worked best because in most people cholesterol biosynthesis takes place in the early morning hours.
However that is not the case with Lipitor, Crestor or Pravachol, since they have half lives of 19-22 hours and therefore morning admiistration would be more suitable.