Archive for August, 2010

• Laboratory, animal, and epidemiologic evidence suggest that vitamin D may be protective against some cancers. Clinical studies now show vitamin D deficiency to be associated with four of the most common cancers.
• It is well established that vitamin D acts as an effective regulator of cell growth and differentiation in a number of different cell types, including cancer cells. Through this action, Vitamin D behaves as a protective factor which decreases the risk of getting cancer.
• Vitamin D may also go beyond cancer prevention and provide tumor therapy. Much ado has been made of pharmaceutical angiogenesis inhibitors agents that help inhibit the growth of new, undesirable blood vessels that tumors require for nutrient supply and growth. Laboratory tests have shown vitamin D to be a potent angiogenesis inhibitor.
• Vitamin D deficiency has been linked with obesity. Vitamin D has recently been shown to lower leptin secretion. Leptin is a hormone produced by fat cells and is involved in weight regulation. It is thought that the hormone signals the brain when fat cells are “full,” but exactly how the hormone controls weight is not entirely clear.
• Infertility is associated with low vitamin D, and PMS has been completely reversed by addition of calcium, magnesium and vitamin D and activated vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine and norepinephrine. Also, low vitamin D may contribute to chronic fatigue and depression. Seasonal Affective Disorder has been treated successfully with vitamin D.

Vitamin D (cholecalciferol) is a pre-hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone.Vitamin D is metabolized into a potent steroid hormone called calcitriol, More recently, it has become clear that receptors for calcitriol, are present in a wide variety of cells, and that calcitriol, has biologic effects which extend far beyond control of mineral metabolism.It is believed that vitamin D and its metabolites, play an important part in the regulation of genes involved in cell growth, differentiation and proliferation. By promoting differentiation and inhibiting proliferation, vitamin D may become an important factor in cancer prevention and therapy.Vitamin D may play a role in the prevention and/or treatment of the following health conditions: atherosclerosis, heart disease, hypertension, breast cancer, colon cancer, prostate cancer, skin cancer, kidney disease, liver disease, multiple sclerosis, muscle weakness, chronic pain, osteoporosis, osteoarthritis, periodontal disease, preeclampsia, psoriasis, tinnitus, mental illness, depression, epilepsy, diabetes, obesity, ulcerative colitis, inflammatory bowel disease, etc.Exposure to sunlight is an important source of vitamin D. Ultraviolet (UV) rays from sunlight trigger vitamin D synthesis in the skin. Many populations through out the world are exposed to quite suboptimal levels of sunlight, especially during the winter months.In addition to geographical and seasonal factors, ultraviolet light from the sun may also be blocked by air pollution. The tendency to wear clothes, to live in cities where tall buildings block adequate sunlight from reaching the ground, etc, all contribute to the inability of the skin to biosynthesize sufficient amounts of vitamin D3.Under these conditions vitamin D becomes a true vitamin, in the sense that it must be supplied in the diet on a regular basis.

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