They may switch you if you bring it up. But their real interest is money and they both enhance their pockets. Heres the scoop on both:
Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients (see WARNINGS). After initiation of ACTOS, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop, the heart failure should be managed according to the current standards of care. Furthermore, discontinuation or dose reduction of ACTOS must be considered
The “glitazone” diabetes drugs Actos and Avandia may double or triple the risk of broken bones after a year or two of use.
The finding comes from Swiss researchers who analyzed 12 years of data on U.K. diabetes patients. They compared the 1,020 patients who suffered some kind of fracture to 3,728 matched patients who did not break any bones.
Over the course of the study, most of the patients took several diabetes drugs. But those who refilled their Actos or Avandia prescriptions eight times or more — about 12 to 18 months of use — had nearly twice the fracture risk of other patients.
And those who refilled their Actos or Avandia prescriptions 15 times or more — two or more years of treatment — nearly tripled their risk of fracture, found Christophe R. Meier, PhD, head of pharmacoepidemiology research at University Hospital Basel, Switzerland, and colleagues.
Metformin is the best of the three.Less side effects.
They may switch you if you bring it up. But their real interest is money and they both enhance their pockets. Heres the scoop on both:
Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients (see WARNINGS). After initiation of ACTOS, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop, the heart failure should be managed according to the current standards of care. Furthermore, discontinuation or dose reduction of ACTOS must be considered
The “glitazone” diabetes drugs Actos and Avandia may double or triple the risk of broken bones after a year or two of use.
The finding comes from Swiss researchers who analyzed 12 years of data on U.K. diabetes patients. They compared the 1,020 patients who suffered some kind of fracture to 3,728 matched patients who did not break any bones.
Over the course of the study, most of the patients took several diabetes drugs. But those who refilled their Actos or Avandia prescriptions eight times or more — about 12 to 18 months of use — had nearly twice the fracture risk of other patients.
And those who refilled their Actos or Avandia prescriptions 15 times or more — two or more years of treatment — nearly tripled their risk of fracture, found Christophe R. Meier, PhD, head of pharmacoepidemiology research at University Hospital Basel, Switzerland, and colleagues.
Metformin is the best of the three.Less side effects.
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